Out goes 795 games of experience, with Joel Bowden, Jordie McMahon, Troy Simmonds, Mark Coughlan and Kayne Pettifer all omitted.
In comes Tyrone Vickery for his first game, Angus Graham, Shane Edwards, Robbie Nahas and Tom Hislop.
With the inclusions having just 64 games between them, that's a differential of 731 games.
Football manager Ross Monaghan said the changes were based on form.
"Robbie missed last week with a corkie, and if it hadn't been such a short week he'd probably have played, so he's 100 per cent," Monaghan told richmondfc.com.au.
"Gus has had one game back with Coburg after his hammy, so he's right to go as well.
"Tommy Hislop's been in some good form with Coburg, as has Shane Edwards.
"And Ty is in for his first game, of course."
RICHMOND'S ROUND 12 TEAM
B: Chris Newman, Kelvin Moore, Dean Polo
HB: Shane Edwards, Luke McGuane, Will Thursfield
C: Andrew Collins, Shane Tuck, Brett Deledio
HF: Richard Tambling, Jack Riewoldt, Ben Cousins
F: Adam Pattison, Mitch Morton, Robin Nahas
Foll: Angus Graham, Daniel Jackson, Nathan Foley
I/C: Trent Cotchin, Tom Hislop, Alex Rance, Tyrone Vickery
Emg: Jake King, Jarrad Oakley-Nicholls, Adam Thomson
In: Vickery, Edwards, Nahas, Graham, Hislop
Out: Joel Bowden, Troy Simmonds, Mark Coughlan, Jordan McMahon, Kayne Pettifer
New: Tyrone Vickery (Sandringham)
