Richmond will unveil two debutants against Port Adelaide on Sunday at Adelaide Oval.
Brown was selected by Richmond with pick No. 17 in the 2021 NAB AFL Draft from the Murray Bushrangers.
The 186cm defender missed the first half of this year with a persistent wrist injury, but has been staking his claim for a 2023 debut after building excellent form in the VFL.
In his 10 outings through the remaining half of the VFL season, the 20-year-old has averaged 19 disposals per game, his decision-making and contest work, both in the air and at ground level, key features of his game.
Tigers' VFL coach Steve Morris said Brown was ready for his opportunity on the big stage after an 18-disposal, six-mark performance against North Melbourne last weekend.
"He used the ball brilliantly throughout the game," Morris said.
"His decision-making and ball use is at a high level at AFL standard, and when he's playing at VFL level it really stands out."
Trezise, 21, was elevated from Richmond's VFL side in the 2023 Mid-Season Rookie Draft, taken with the Club's second selection (No. 13 overall).
When he was recruited from Tooradin-Dalmore to the Tigers' VFL program ahead of the 2023 season, Trezise had never previously been in a state league program or elite junior program.
The rebounding defender, who stands at 188cm, had clear raw talent and was recognised for his work ethic.
An exciting left-footer, Trezise has been a reliable pillar in defence for the VFL Tigers throughout his 18 matches in 2023.
He was a key contributor in last Sunday's 12-point win, collecting 18 disposals, four marks and three inside-50s.
Hard-tackling and strong aerially, Morris said Trezise had consistently stood out and was equally ready for his opportunity.
"(He has) continued his good form," Morris said of Trezise after the weekend's VFL game.
"He impacted both in the air and at ground level, and continues to excite fans."
Richmond will confirm its final team for the trip to Adelaide on Friday night at 5.00pm AEST.