Shane Tuck (ribs) returns after injury, while Mitch Farmer and Andrew Browne will make their first appearances in the Tiger line-up this season.
They replace Shane Edwards, who sustained a fractured cheekbone in last Sunday’s loss to the Western Bulldogs at Etihad Stadium, and Angus Graham and Ben Nason, who have both been omitted.
Tuck has been sidelined since damaging his ribs in Richmond’s Round 6 victory over Brisbane at the MCG.
Jeromey Webberley, David Astbury and Jayden Post have been named as the Tigers’ emergencies for Saturday night’s game.